Research themes

    Endo-Lysosomal Biology

    Membrane Trafficking

    Autophagy

    Neuronal Cell Biology

    Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.

    Cancer Cell Biology

    Role and regulation of endo-lysosomal system in cancerogenesis.

    Correlative Light and Electron Microscopy

    Development and Utilization of Correlative Microscopy Techniques for Intracellular Studies

    Research projects

    • HOPS and CORVET: Multisubunit tethers of the endo-lysosomal system in health and disease

    • Autophagic and endo-lysosomal dysfunction in neurodegenerative diseases

    • Lysosomal subpopulations in cancerogenesis

    • CHEVI complex in regulation of endo-lysosomal trafficking

    • Spatial and temporal regulation of endo-lysosomal processes in lipid metabolism

    • Development and Utilization of Correlative Microscopy Techniques for Intracellular Studies

    Collaborations

    We collaborate with inter(national) scientists on cell biology and advanced microscopy related topics. Want to collaborate with us? Contact Nalan (n.liv@umcutrecht.nl) or Judith (j.klumperman@umcutrecht.nl).